Got cancelled after one season and fans have been in a state of mourning for twenty-odd years now.
Fun fact: Fox cancelled the show after airing just 11 of 14 produced episodes, then it spawned a feature film.
Giant naked people eating regular-sized people, and somehow it's one of the most emotionally devastating shows around.
Fun fact: Shōnen Jump rejected the manuscript before Kodansha published it and it sold over 110 million copies.