A grumpy genius with a cane solves medical mysteries nobody else can, mostly by being rude to everyone in the hospital.
Fun fact: Hugh Laurie's American accent was so convincing that Bryan Singer initially didn't know he was British.
Giant naked people eating regular-sized people, and somehow it's one of the most emotionally devastating shows around.
Fun fact: Shōnen Jump rejected the manuscript before Kodansha published it and it sold over 110 million copies.